Anti-Cancer Drug Discovery and Development
Continuous Anticancer drug discovery and development is critical to find a complete cure for cancer. Due to the drug resistance developed by tumour cells for existing treatments, this is becoming a mandatory approach to fight the disease.
- Various kinase enzymes are important in control of cell growth and the replication cycle. These can act as regulators of cell division checkpoints to ensure the integrity of DNA replication through sensing DNA damage and initiating repair, while halting cell cycle. Many cancerous cells are deficient in DNA damage checkpoints due to deletion or mutation in p53 pathway. This provides an opportunity to selectively target tumour cells to enhance the ionization effect or widely used DNA damaging cancer chemotherapies.
- Scientific investigation on inhibitors of checkpoint CHK1 can be another milestone for anticancer drug discovery approach.
- Cancer cells are specifically dependent on molecular chaperones and related proteins that regulate homeostasis. These are promising targets for new anticancer therapies.
- Deregulated apoptosis is hallmark of cancer and Bcl-2 family of proteins are pivotal to mediating the pathway of this process. Inhibiting their process can e a significant way for developing new anticancer drugs. Many plant sources are known to be valuable sources of novel anti-cancer properties.