Cancer Epigenetics and Oncogenomics
Cancer epigenetics is the study of heritable changes in gene activity or expression without altering the nucleotide sequences in the genetic material. Examples of these types of changes include DNA methylation and histone modification.in different types of cancer. A variety of epigenetic modifications can be applied such as silencing of tumour suppressor genes or activation of oncogenes, histone modification or dysregulation of DNA binding proteins.
Oncogenomics is a sub-field of genomics that deals with the characterization of cancer associated genes. More specifically, it focuses on the genomic, epigenomic and transcriptomic alterations in cancer. It also deals with the identification of novel tumour suppressing genes that may be used to find new treatment approach.